Communications Biology (May 2022)

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels

  • Mahesh Kondapuram,
  • Benedikt Frieg,
  • Sezin Yüksel,
  • Tina Schwabe,
  • Christian Sattler,
  • Marco Lelle,
  • Andrea Schweinitz,
  • Ralf Schmauder,
  • Klaus Benndorf,
  • Holger Gohlke,
  • Jana Kusch

DOI
https://doi.org/10.1038/s42003-022-03360-6
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 14

Abstract

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Interactions between opposite subunits of HCN channels are relevant for stabilizing the auto-inhibited state of the channel. Like cAMP-binding, K464E-mutation breaks these interactions to favor a channel’s pre-activated state.