We demonstrate the use of a graded-index perfluorinated optical fiber (GI-POF) for distributed static and dynamic strain measurements based on Rayleigh scattering. The system is based on an amplitude-based phase-sensitive Optical Time-Domain Reflectometry (ϕ-OTDR) configuration, operated at the unconventional wavelength of 850 nm. Static strain measurements have been carried out at a spatial resolution of 4 m and for a strain up to 3.5% by exploiting the increase of the backscatter Rayleigh coefficient consequent to the application of a tensile strain, while vibration/acoustic measurements have been demonstrated for a sampling frequency up to 833 Hz by exploiting the vibration-induced changes in the backscatter Rayleigh intensity time-domain traces arising from coherent interference within the pulse. The reported tests demonstrate that polymer optical fibers can be used for cost-effective multiparameter sensing.