mTORC1 accelerates retinal development via the immunoproteasome

Ji-Heon Choi; Hong Seok Jo; Soyeon Lim; Hyoung-Tai Kim; Kang Woo Lee; Kyeong Hwan Moon; Taejeong Ha; Sang Soo Kwak; Yeha Kim; Eun Jung Lee; Cheol O. Joe; Jin Woo Kim

doi:10.1038/s41467-018-04774-9

Nature Communications (Jun 2018)

mTORC1 accelerates retinal development via the immunoproteasome

Ji-Heon Choi,
Hong Seok Jo,
Soyeon Lim,
Hyoung-Tai Kim,
Kang Woo Lee,
Kyeong Hwan Moon,
Taejeong Ha,
Sang Soo Kwak,
Yeha Kim,
Eun Jung Lee,
Cheol O. Joe,
Jin Woo Kim

Affiliations

Ji-Heon Choi: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Hong Seok Jo: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Soyeon Lim: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Hyoung-Tai Kim: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Kang Woo Lee: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Kyeong Hwan Moon: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Taejeong Ha: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Sang Soo Kwak: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Yeha Kim: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Eun Jung Lee: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Cheol O. Joe: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Jin Woo Kim: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)

DOI: https://doi.org/10.1038/s41467-018-04774-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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One of the determinants of the neuronal subtype produced from retinal progenitor cells is their proliferative potential. Here the authors show that mTORC1 promotes progenitor cell cycle progression and hence accelerated development in mouse retina through induction of the immunoproteasome which enhances the degradation of cyclins.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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