Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

Xiaoli Cai; Mingming Wang; Peng Mu; Tengyue Jian; Dong Liu; Shichao Ding; Yanan Luo; Dan Du; Yang Song; Chun-Long Chen; Yuehe Lin

doi:10.34133/2021/9861384

Research (Jan 2021)

Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

Xiaoli Cai,
Mingming Wang,
Peng Mu,
Tengyue Jian,
Dong Liu,
Shichao Ding,
Yanan Luo,
Dan Du,
Yang Song,
Chun-Long Chen,
Yuehe Lin

Affiliations

Xiaoli Cai: School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, USA
Mingming Wang: Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
Peng Mu: Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA; Department of Mechanical Engineering and Materials Science and Engineering Program, State University of New York, Binghamton, New York 13902, USA
Tengyue Jian: Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
Dong Liu: School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, USA
Shichao Ding: School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, USA
Yanan Luo: School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, USA
Dan Du: School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, USA
Yang Song: School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, USA
Chun-Long Chen: Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
Yuehe Lin: School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, USA

DOI: https://doi.org/10.34133/2021/9861384
Journal volume & issue: Vol. 2021

Abstract

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Near-infrared (NIR) laser-induced phototherapy through NIR agents has demonstrated the great potential for cancer therapy. However, insufficient tumor killing due to the nonuniform heat or cytotoxic singlet oxygen (1O2) distribution over tumors from phototherapy results in tumor recurrence and inferior outcomes. To achieve high tumor killing efficacy, one of the solutions is to employ the combinational treatment of phototherapy with other modalities, especially with chemotherapeutic agents. In this paper, a simple and effective multimodal therapeutic system was designed via combining chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) to achieve the polytherapy of malignant glioma which is one of the most aggressive tumors in the brain. IR-780 (IR780) dye-labeled tube-forming peptoids (PepIR) were synthesized and self-assembled into crystalline nanotubes (PepIR nanotubes). These PepIR nanotubes showed an excellent efficacy for PDT/PTT because the IR780 photosensitizers were effectively packed and separated from each other within crystalline nanotubes by tuning IR780 density; thus, a self-quenching of these IR780 molecules was significantly reduced. Moreover, the efficient DOX loading achieved due to the nanotube large surface area contributed to an efficient and synergistic chemotherapy against glioma cells. Given the unique properties of peptoids and peptoid nanotubes, we believe that the developed multimodal DOX-loaded PepIR nanotubes in this work offer great promises for future glioma therapy in clinic.

Published in Research

ISSN: 2096-5168 (Print); 2639-5274 (Online)
Publisher: American Association for the Advancement of Science (AAAS)
Country of publisher: United States
LCC subjects: Science
Website: https://spj.science.org/journal/research

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