Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters

Aimee H. Marceau; Jessica G. Felthousen; Paul D. Goetsch; Audra N. Iness; Hsiau-Wei Lee; Sarvind M. Tripathi; Susan Strome; Larisa Litovchick; Seth M. Rubin

doi:10.1038/ncomms12301

Nature Communications (Jul 2016)

Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters

Aimee H. Marceau,
Jessica G. Felthousen,
Paul D. Goetsch,
Audra N. Iness,
Hsiau-Wei Lee,
Sarvind M. Tripathi,
Susan Strome,
Larisa Litovchick,
Seth M. Rubin

Affiliations

Aimee H. Marceau: Department of Chemistry and Biochemistry, University of California
Jessica G. Felthousen: Division of Hematology, Oncology and Palliative Care and Massey Cancer Center, Virginia Commonwealth University
Paul D. Goetsch: Department of Molecular, Cell and Developmental Biology, University of California
Audra N. Iness: Division of Hematology, Oncology and Palliative Care and Massey Cancer Center, Virginia Commonwealth University
Hsiau-Wei Lee: Department of Chemistry and Biochemistry, University of California
Sarvind M. Tripathi: Department of Chemistry and Biochemistry, University of California
Susan Strome: Department of Molecular, Cell and Developmental Biology, University of California
Larisa Litovchick: Division of Hematology, Oncology and Palliative Care and Massey Cancer Center, Virginia Commonwealth University
Seth M. Rubin: Department of Chemistry and Biochemistry, University of California

DOI: https://doi.org/10.1038/ncomms12301
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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The MuvB complex, which regulates cell cycle dependent gene expression, binds promoter cell cycle genes homology region (CHR) elements. Here the authors solve the structure of LIN54, a component of MuvB, bound to DNA and use it to explain the recognition of a CHR sequence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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