Prospective, Controlled, Multicentre Study of Loperimide in Pregnancy

A Einarson; P Mastroiacovo; J Arnon; A Ornoy; A Addis; H Malm; G Koren

doi:10.1155/2000/957649

Canadian Journal of Gastroenterology (Jan 2000)

Prospective, Controlled, Multicentre Study of Loperimide in Pregnancy

A Einarson,
P Mastroiacovo,
J Arnon,
A Ornoy,
A Addis,
H Malm,
G Koren

Affiliations

A Einarson: The Motherisk Program, The Hospital For Sick Children, University of Toronto, Toronto, Ontario, Canada
P Mastroiacovo: Birth Defects Unit and Telefono Rosso, lnstitute of Pediatrics, Catholic University, Rome, Italy
J Arnon: Laboratory of Teratology, Hebrew University, Jerusalem, Israel
A Ornoy: Laboratory of Teratology, Hebrew University, Jerusalem, Israel
A Addis: Mario Negri Institute, Milan, Italy
H Malm: The Family Federation of Finland, Department of Genetics, Helsinki, Finland
G Koren: The Motherisk Program, The Hospital For Sick Children, University of Toronto, Toronto, Ontario, Canada

DOI: https://doi.org/10.1155/2000/957649
Journal volume & issue: Vol. 14, no. 3
pp. 185 – 187

Abstract

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BACKGROUND: Loperamide is a synthetic piperidine derivative used for the treatment of both acute and chronic diarrhea. Little is known about its safety and risk in pregnancy. Human data are limited to one surveillance study of Michigan Medicaid patients, with 108 women exposed in the first trimester. In this study there were six major birth defects, three of which were cardiovascular anomalies.

Published in Canadian Journal of Gastroenterology

ISSN: 0835-7900 (Print); 1916-7237 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://onlinelibrary.wiley.com/journal/1720

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