A novel multicomponent reaction between amino acids, aromatic aldehydes and p-toluenesulfonylmethyl isocyanide: an efficient and green one-pot synthesis using nanosilica

Abstract

The novel diastereomeric sulfonylamide derivatives 4a–h were synthesized by multi-component reactions between (l)-α-amino acids, 1, aromatic aldehydes, 2 and p-toluenesulfonylmethyl isocyanide, 3 in water/methanol using nanosilica as a catalyst. The one-pot green reactions were carried out at room temperature with a quantitative yield in water/methanol. The yield of the reactions and products was determined and discussed. The reusablity of the catalyst is discussed.

Keywords

• Ugi reaction
• tosyl acyloxy amino carboxamide derivatives
• amino acid
• aromatic aldehydes
• toluenesulfonylmethyl isocyanide
• silica nanoparticles