Stem Cell Research (Sep 2024)

Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the PSEN1 H163R mutation

  • Damián Hernández,
  • Stephanie Morgan Schlicht,
  • Jordan Elli Clarke,
  • Maciej Daniszewski,
  • Celeste M. Karch,
  • Alison M. Goate,
  • Alice Pébay,
  • Sarah Adams,
  • Ricardo Allegri,
  • Aki Araki,
  • Nicolas Barthelemy,
  • Randall Bateman,
  • Jacob Bechara,
  • Tammie Benzinger,
  • Sarah Berman,
  • Courtney Bodge,
  • Sus Brandon,
  • William (Bill) Brooks,
  • Jared Brosch,
  • Jill Buck,
  • Virginia Buckles,
  • Kathleen Carter,
  • Lisa Cash,
  • Charlie Chen,
  • Jasmeer Chhatwal,
  • Patricio Chrem Mendez,
  • Jasmin Chua,
  • Helena Chui,
  • Laura Courtney,
  • Carlos Cruchaga,
  • Gregory S Day,
  • Chrismary DeLaCruz,
  • Darcy Denner,
  • Anna Diffenbacher,
  • Aylin Dincer,
  • Tamara Donahue,
  • Jane Douglas,
  • Duc Duong,
  • Noelia Egido,
  • Bianca Esposito,
  • Anne Fagan,
  • Marty Farlow,
  • Becca Feldman,
  • Colleen Fitzpatrick,
  • Shaney Flores,
  • Nick Fox,
  • Erin Franklin,
  • Nelly Joseph-Mathurin,
  • Hisako Fujii,
  • Samantha Gardener,
  • Bernardino Ghetti,
  • Alison Goate,
  • Sarah Goldberg,
  • Jill Goldman,
  • Alyssa Gonzalez,
  • Brian Gordon,
  • Susanne Gr¨aber-Sultan,
  • Neill Graff-Radford,
  • Morgan Graham,
  • Julia Gray,
  • Emily Gremminger,
  • Miguel Grilo,
  • Alex Groves,
  • Christian Haass,
  • Lisa H¨asler,
  • Jason Hassenstab,
  • Cortaiga Hellm,
  • Elizabeth Herries,
  • Laura Hoechst-Swisher,
  • Anna Hofmann,
  • Anna Hofmann,
  • David Holtzman,
  • Russ Hornbeck,
  • Yakushev Igor,
  • Ryoko Ihara,
  • Takeshi Ikeuchi,
  • Snezana Ikonomovic,
  • Kenji Ishii,
  • Clifford Jack,
  • Gina Jerome,
  • Erik Johnson,
  • Mathias Jucker,
  • Celeste Karch,
  • Stephan K¨aser,
  • Kensaku Kasuga,
  • Sarah Keefe,
  • William Klunk,
  • Robert Koeppe,
  • Deb Koudelis,
  • Elke Kuder-Buletta,
  • Christoph Laske,
  • Allan Levey,
  • Johannes Levin,
  • Yan Li,
  • Oscar Lopez,
  • Jacob Marsh,
  • Ralph Martins,
  • Neal Scott Mason,
  • Colin Masters,
  • Kwasi Mawuenyega,
  • Austin McCullough,
  • Eric McDade,
  • Arlene Mejia,
  • Estrella Morenas-Rodriguez,
  • John Morris,
  • James Mountz,
  • Cath Mummery,
  • Neelesh Nadkarni,
  • Akemi Nagamatsu,
  • Katie Neimeyer,
  • Yoshiki Niimi,
  • James Noble,
  • Joanne Norton,
  • Brigitte Nuscher,
  • Ulricke Obermüller,
  • Antoinette O’Connor,
  • Riddhi Patira,
  • Richard Perrin,
  • Lingyan Ping,
  • Oliver Preische,
  • Alan Renton,
  • John Ringman,
  • Stephen Salloway,
  • Peter Schofield,
  • Michio Senda,
  • Nicholas T Seyfried,
  • Kristine Shady,
  • Hiroyuki Shimada,
  • Wendy Sigurdson,
  • Jennifer Smith,
  • Lori Smith,
  • Beth Snitz,
  • Hamid Sohrabi,
  • Sochenda Stephens,
  • Kevin Taddei,
  • Sarah Thompson,
  • Jonathan V¨oglein,
  • Peter Wang,
  • Qing Wang,
  • Elise Weamer,
  • Chengjie Xiong,
  • Jinbin Xu,
  • Xiong Xu

Journal volume & issue
Vol. 79
p. 103495

Abstract

Read online

We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer’s disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.