Polyaniline Functionalized Peptide Self-Assembled Conductive Hydrogel for 3D Cell Culture
Jieling Li,
Yan Xue,
Anhe Wang,
Shaonan Tian,
Qi Li,
Shuo Bai
Affiliations
Jieling Li
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 North 2nd Street, Zhongguancun, Beijing 100190, China
Yan Xue
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 North 2nd Street, Zhongguancun, Beijing 100190, China
Anhe Wang
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 North 2nd Street, Zhongguancun, Beijing 100190, China
Shaonan Tian
Modular Platform Public Instrument Center, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
Qi Li
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 North 2nd Street, Zhongguancun, Beijing 100190, China
Shuo Bai
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 North 2nd Street, Zhongguancun, Beijing 100190, China
The functionalization of self-assembled peptide hydrogel is of great importance to broaden its applications in the field of biomedicine. In this work, conductive hydrogel is fabricated by introducing conductive polymer polyaniline into peptide self-assembled hydrogel. Compared with pure peptide formed hydrogel, the conductive hydrogel exhibits enhanced conductivity, mechanical property and stability. In addition, the hydrogel is tested to be of great injectability and 3D bio-printability and could support the viability of encapsulated cells that are sensitive to electrical signals. It should have great application prospects in the preparation of tissue engineering scaffolds.
