Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale

Alessio Rungatscher; Maddalena Tessari; Chiara Stranieri; Erika Solani; Daniele Linardi; Elisabetta Milani; Alessio Montresor; Flavia Merigo; Beatrice Salvetti; Tiziano Menon; Giuseppe Faggian

doi:10.1155/2015/484979

Mediators of Inflammation (Jan 2015)

Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale

Alessio Rungatscher,
Maddalena Tessari,
Chiara Stranieri,
Erika Solani,
Daniele Linardi,
Elisabetta Milani,
Alessio Montresor,
Flavia Merigo,
Beatrice Salvetti,
Tiziano Menon,
Giuseppe Faggian

Affiliations

Alessio Rungatscher: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy
Maddalena Tessari: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy
Chiara Stranieri: Section of General Pathology, Department of Pathology and Diagnostics, University of Verona, 37126 Verona, Italy
Erika Solani: Section of General Pathology, Department of Pathology and Diagnostics, University of Verona, 37126 Verona, Italy
Daniele Linardi: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy
Elisabetta Milani: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy
Alessio Montresor: Section of General Pathology, Department of Pathology and Diagnostics, University of Verona, 37126 Verona, Italy
Flavia Merigo: Department of Neurological and Movement Sciences, University of Verona, 37126 Verona, Italy
Beatrice Salvetti: Department of Neurological and Movement Sciences, University of Verona, 37126 Verona, Italy
Tiziano Menon: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy
Giuseppe Faggian: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy

DOI: https://doi.org/10.1155/2015/484979
Journal volume & issue: Vol. 2015

Abstract

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In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated fundamental information on the role of oxygenator of ECC in activating inflammatory signaling pathways on leukocytes, leading to systemic inflammatory response, and organ dysfunction. The present results suggest that experimental animal models of ECC used in translational research on inflammatory response should be based on standardized, reproducible oxygenators with clinical characteristics.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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