Efficacy and safety of Bruton's tyrosine kinase inhibitors in the treatment of pemphigus: A comprehensive literature review and future perspective
Yekta Ghane,
Nazila Heidari,
Amirhossein Heidari,
Sara Sadeghi,
Azadeh Goodarzi
Affiliations
Yekta Ghane
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Nazila Heidari
School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Amirhossein Heidari
Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Sara Sadeghi
Department of Medicine, New York Health System, South Brooklyn Hospital, NY, USA; Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Corresponding author. Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Azadeh Goodarzi
Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Corresponding author.
Bruton's tyrosine kinase (BTK) is a protein involved in B-cell-receptor signaling and B-cell proliferation. The pathophysiology of several autoimmune diseases, such as pemphigus disorder, relies on the BTK signaling pathway. Therefore, BTK inhibitors were found to be beneficial alternatives to conventional treatmentsThe current study aimed to assess the efficacy and safety of BTK inhibitors in treating pemphigus. A complete search was performed on databases including PubMed/MedLine, Scopus, Web of Science, as well as Google Scholar search engine for studies published by September 20th, 2023. The current review indicates that BTK inhibitors alone or in combination with conventional treatments are promising options in the management of pemphigus. The overall safety profile of BTK inhibitors has been acceptable, and the reported adverse reactions were not severe or life-threatening.
