Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators

Abstract

Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth.

Keywords

• cyclohexenonic long-chain fatty alcohol
• neurite outgrowth
• neuronal survival
• neurotrophic compound
• neurotrophic factor
• NGF
• synthesis