INHERITED PROTEIN C AND PROTEIN S DEFICIENCY IN RENAL TRANSPLANT CANDIDATES OF SINDH PROVINCE, PAKISTAN

Abstract

Background: Thrombophilia is a common risk factor for venous thromboembolism. The objective of this study was to determine prevalence of inherited protein C and protein S deficiency in renal transplant candidates of Sindh Province, Pakistan. Material & Methods: This cross-sectional study was conducted in Department of Pathology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan from 16-10-2010 to 15-4-2011. 300 renal transplant candidates were selected. Candidates with acquired thrombotic disorders, women taking oral contraceptives and patients taking anti-coagulants during previous one week were excluded. Venous blood samples were collected before starting dialysis procedure or at least two days after last dialysis session. Platelet-poor plasma (PPP) was parted using plastic pipettes and protein C and protein S were processed on coagulation analyzer. Sex, age groups (

Keywords

• thrombophilia, protein c, protein s, protein c deficiency
• protein s deficiency
• venous thromboembolism
• oral contraceptives
• dialysis
• end-stage renal disease
• renal transplantation.