Synthesis of heterocyclic compounds and its applications

Mohan N. Patel; Parag S. Karia; Pankajkumar A. Vekariya; Anshul P. Patidar

Arabian Journal of Chemistry (Dec 2019)

Synthesis of heterocyclic compounds and its applications

Mohan N. Patel,
Parag S. Karia,
Pankajkumar A. Vekariya,
Anshul P. Patidar

Affiliations

Mohan N. Patel: Corresponding author. Tel.: +91 (2692) 226856x218.; Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India
Parag S. Karia: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India
Pankajkumar A. Vekariya: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India
Anshul P. Patidar: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India

Journal volume & issue: Vol. 12, no. 8
pp. 2983 – 2991

Abstract

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The octahedral ruthenium(II) complexes [Ru(Ln)(PPh3)2Cl2] [Ln = biphenyl furanyl pyridine derivatives] were synthesized and characterized using LC–MS, IR spectroscopy, elemental analysis and magnetic measurements. Complexes show enhancement in antibacterial activity compared to free ligands. From the binding mode investigation by absorption titration and viscosity measurement, it is observed that complexes bind to DNA via intercalation and also complexes promote the cleavage of supercoiled pUC19 plasmid DNA. Cytotoxicity analysis shows 100% mortality of Brine shrimp after 48 h. Keywords: Heterocyclic compound, Ruthenium(II) complexes, Nucleic acid intercalating agent, Cytotoxicity

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

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