Structural and functional reorganization of contralateral hippocampus after temporal lobe epilepsy surgery

Wei Li; Yuchao Jiang; Yingjie Qin; Baiwan Zhou; Du Lei; Heng Zhang; Ding Lei; Dezhong Yao; Cheng Luo; Qiyong Gong; Dong Zhou; Dongmei An

NeuroImage: Clinical (Jan 2021)

Structural and functional reorganization of contralateral hippocampus after temporal lobe epilepsy surgery

Wei Li,
Yuchao Jiang,
Yingjie Qin,
Baiwan Zhou,
Du Lei,
Heng Zhang,
Ding Lei,
Dezhong Yao,
Cheng Luo,
Qiyong Gong,
Dong Zhou,
Dongmei An

Affiliations

Wei Li: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Yuchao Jiang: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Yingjie Qin: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Baiwan Zhou: Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Du Lei: Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Heng Zhang: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Ding Lei: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Dezhong Yao: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Cheng Luo: The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Qiyong Gong: Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Corresponding authors at: Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Q. Gong). Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China (D. Zhou and D. An).
Dong Zhou: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Corresponding authors at: Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Q. Gong). Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China (D. Zhou and D. An).
Dongmei An: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Corresponding authors at: Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Q. Gong). Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China (D. Zhou and D. An).

Journal volume & issue: Vol. 31
p. 102714

Abstract

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Objective: To explore the structural and functional reorganization of contralateral hippocampus in patients with unilateral mesial temporal lobe epilepsy (mTLE) who achieved seizure-freedom after anterior temporal lobectomy (ATL). Methods: We obtained high-resolution structural MRI and resting-state functional MRI data in 28 unilateral mTLE patients and 29 healthy controls. Patients were scanned before and three and 24 months after surgery while controls were scanned only once. Hippocampal gray matter volume (GMV) and functional connectivity (FC) were assessed. Results: No obvious GMV changes were observed in contralateral hippocampus before and after successful surgery. Before surgery, ipsilateral hippocampus showed increased FC with ipsilateral insula (INS) and temporoparietal junction (TPJ), but decreased FC with widespread bilateral regions, as well as contralateral hippocampus. After successful ATL, contralateral hippocampus showed: (1) decreased FC with ipsilateral INS at three months follow-up, without further changes; (2) decreased FC with ipsilateral TPJ, postcentral gyrus and rolandic operculum at three months, with an obvious increase at 24 months follow-up; (3) increased FC with bilateral medial prefrontal cortex (MPFC) and superior frontal gyrus (SFG) at three months follow-up, without further changes. Conclusions: Successful ATL may not lead to an obvious structural reorganization in contralateral hippocampus. Surgical manipulation may lead to a transient FC reduction of contralateral hippocampus. Increased FC between contralateral hippocampus and bilateral MPFC and SFG may be related to postoperative functional remodeling.

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

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