Frontiers in Veterinary Science (Dec 2021)
Proposed Diagnostic Criteria and Classification of Canine Mast Cell Neoplasms: A Consensus Proposal
- Michael Willmann,
- Michael Willmann,
- Vilma Yuzbasiyan-Gurkan,
- Laura Marconato,
- Mauro Dacasto,
- Emir Hadzijusufovic,
- Emir Hadzijusufovic,
- Emir Hadzijusufovic,
- Olivier Hermine,
- Irina Sadovnik,
- Irina Sadovnik,
- Susanne Gamperl,
- Susanne Gamperl,
- Mathias Schneeweiss-Gleixner,
- Mathias Schneeweiss-Gleixner,
- Karoline V. Gleixner,
- Thomas Böhm,
- Barbara Peter,
- Barbara Peter,
- Gregor Eisenwort,
- Gregor Eisenwort,
- Richard Moriggl,
- Zhixiong Li,
- Mohamad Jawhar,
- Karl Sotlar,
- Erika Jensen-Jarolim,
- Erika Jensen-Jarolim,
- Veronika Sexl,
- Hans-Peter Horny,
- Hans-Peter Horny,
- Stephen J. Galli,
- Stephen J. Galli,
- Michel Arock,
- David M. Vail,
- David M. Vail,
- Matti Kiupel,
- Peter Valent,
- Peter Valent
Affiliations
- Michael Willmann
- Department/Hospital for Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna, Austria
- Michael Willmann
- Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
- Vilma Yuzbasiyan-Gurkan
- Comparative Medicine and Integrative Biology Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI, United States
- Laura Marconato
- Department of Veterinary Medical Science, University of Bologna, Ozzano dell'Emilia, Italy
- Mauro Dacasto
- Department of Comparative Biomedicine and Food Science, University of Padua, Padua, Italy
- Emir Hadzijusufovic
- Department/Hospital for Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna, Austria
- Emir Hadzijusufovic
- Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
- Emir Hadzijusufovic
- Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
- Olivier Hermine
- Department of Hematology, Imagine Institute Université de Paris, INSERM U1163, CEREMAST, Necker Hospital, Paris, France
- Irina Sadovnik
- Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
- Irina Sadovnik
- Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
- Susanne Gamperl
- Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
- Susanne Gamperl
- Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
- Mathias Schneeweiss-Gleixner
- Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
- Mathias Schneeweiss-Gleixner
- Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
- Karoline V. Gleixner
- Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
- Thomas Böhm
- Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
- Barbara Peter
- Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
- Barbara Peter
- Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
- Gregor Eisenwort
- Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
- Gregor Eisenwort
- Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
- Richard Moriggl
- Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria
- Zhixiong Li
- 0Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hanover Medical School, Hanover, Germany
- Mohamad Jawhar
- 1Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany
- Karl Sotlar
- 2Institute of Pathology, Paracelsus Medical University of Salzburg, Salzburg, Austria
- Erika Jensen-Jarolim
- 3Center of Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria
- Erika Jensen-Jarolim
- 4The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University of Vienna, Vienna, Austria
- Veronika Sexl
- 5Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
- Hans-Peter Horny
- 2Institute of Pathology, Paracelsus Medical University of Salzburg, Salzburg, Austria
- Hans-Peter Horny
- 6Institute of Pathology, Ludwig-Maximilians University, Munich, Germany
- Stephen J. Galli
- 7Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States
- Stephen J. Galli
- 8Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, United States
- Michel Arock
- 9Laboratory of Hematology, Pitié-Salpêtrière Hospital, Paris, France
- David M. Vail
- 0Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States
- David M. Vail
- 1Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States
- Matti Kiupel
- 2Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI, United States
- Peter Valent
- Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
- Peter Valent
- Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
- DOI
- https://doi.org/10.3389/fvets.2021.755258
- Journal volume & issue
-
Vol. 8
Abstract
Mast cell neoplasms are one of the most frequently diagnosed malignancies in dogs. The clinical picture, course, and prognosis vary substantially among patients, depending on the anatomic site, grade and stage of the disease. The most frequently involved organ is the skin, followed by hematopoietic organs (lymph nodes, spleen, liver, and bone marrow) and mucosal sites of the oral cavity and the gastrointestinal tract. In cutaneous mast cell tumors, several grading and staging systems have been introduced. However, no comprehensive classification and no widely accepted diagnostic criteria have been proposed to date. To address these open issues and points we organized a Working Conference on canine mast cell neoplasms in Vienna in 2019. The outcomes of this meeting are summarized in this article. The proposed classification includes cutaneous mast cell tumors and their sub-variants defined by grading- and staging results, mucosal mast cell tumors, extracutaneous/extramucosal mast cell tumors without skin involvement, and mast cell leukemia (MCL). For each of these entities, diagnostic criteria are proposed. Moreover, we have refined grading and staging criteria for mast cell neoplasms in dogs based on consensus discussion. The criteria and classification proposed in this article should greatly facilitate diagnostic evaluation and prognostication in dogs with mast cell neoplasms and should thereby support management of these patients in daily practice and the conduct of clinical trials.
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