A Novel Gene RNF138 Expressed in Human Gliomas and Its Function in the Glioma Cell Line U251

You-xin Zhou; San-song Chen; Ting-feng Wu; Da-dong Ding; Xiong-hui Chen; Jin-ming Chen; Zuo-peng Su; Bin Li; Gui-lin Chen; Xue-shun Xie; Yan-fang Dai; Yong-xin Wei; Zi-wei Du

doi:10.3233/ACP-2011-0051

Analytical Cellular Pathology (Jan 2012)

A Novel Gene RNF138 Expressed in Human Gliomas and Its Function in the Glioma Cell Line U251

You-xin Zhou,
San-song Chen,
Ting-feng Wu,
Da-dong Ding,
Xiong-hui Chen,
Jin-ming Chen,
Zuo-peng Su,
Bin Li,
Gui-lin Chen,
Xue-shun Xie,
Yan-fang Dai,
Yong-xin Wei,
Zi-wei Du

Affiliations

You-xin Zhou: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
San-song Chen: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Ting-feng Wu: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Da-dong Ding: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Xiong-hui Chen: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Jin-ming Chen: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Zuo-peng Su: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Bin Li: The Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Gui-lin Chen: The Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Xue-shun Xie: The Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Yan-fang Dai: The Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Yong-xin Wei: The Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Zi-wei Du: The Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China

DOI: https://doi.org/10.3233/ACP-2011-0051
Journal volume & issue: Vol. 35, no. 3
pp. 167 – 178

Abstract

Read online

Background: The gliomas represent the most common primary malignant brain tumors; however, little is known about the molecular pathogenesis of these tumors. Recent research reveals that the oncogenesis and development of gliomas have a close relation to the overexpression of several oncogenes and the inactivation of tumor suppressor genes. Whether the RING finger protein, RNF138, a newly discovered protein, plays a role in glioma oncogenesis is unknown. The present study investigates the expression levels of RNF138 mRNA in glioma samples and noncancerous brain samples and its function in the human glioma cell line U251.

Published in Analytical Cellular Pathology

ISSN: 2210-7177 (Print); 2210-7185 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://www.hindawi.com/journals/acp/

About the journal