The Role of Wisteria Floribunda (M2BPGi) Serum Level for Diagnosing Liver Fibrosis in Hepatitis B Patient: An Evidence Based Case Report

Abstract

Aim: To assess M2BPGi serum performance compared to liver biopsy in diagnosisng liver fibrosis Method: Literature search using Pubmed®, Ebsco®, ProQuest®, Scopus®, Clinical Key databases, and the Cochrane Library® yield four relevant and full-text articles. The four articles were critically appraised for its validity, importance, and applicability. Results: Sensitivity and specificity in all four studies showed that M2BPGi serum was inadequate to ruling in and ruling out the diagnosis of liver fibrosis in chronic hepatitis B patients. The difference in M2BPGi cut-off value to determine the stage of fibrosis in each study makes this value cannot be used as an accurate standard to determine the advanced stage (F≥3) of liver fibrosis. On the other hand, M2BPGi serum combined with other tests are known to improve the diagnostic accuracy. Conclusion: MBP2Gi serum cannot be used as a diagnostic modality for detecting liver fibrosis in chronic hepatitis B patients.

Keywords

• hepatits b
• fibrosis
• m2bpgi
• wisteria floribunda
• liver biopsy