Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA

Wendan Ren; Jiuwei Lu; Mengjiang Huang; Linfeng Gao; Dongxu Li; Gang Greg Wang; Jikui Song

doi:10.1038/s41467-019-12923-x

Nature Communications (Nov 2019)

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA

Wendan Ren,
Jiuwei Lu,
Mengjiang Huang,
Linfeng Gao,
Dongxu Li,
Gang Greg Wang,
Jikui Song

Affiliations

Wendan Ren: Department of Biochemistry, University of California
Jiuwei Lu: Department of Biochemistry, University of California
Mengjiang Huang: Department of Biochemistry, University of California
Linfeng Gao: Environmental Toxicology Graduate Program, University of California
Dongxu Li: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
Gang Greg Wang: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
Jikui Song: Department of Biochemistry, University of California

DOI: https://doi.org/10.1038/s41467-019-12923-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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The N6-methyladenosine (m6A) RNA modification is an evolutionarily conserved epitranscriptomic mechanism that impacts several cellular processes. Here the authors present a structure-function analysis of the ZCCHC4, 28S RNA-specific m6A methyltransferase, shedding light on its regulation and mechanisms that ensure substrate specificity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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