P-­glycoprotein expression in experimental thyroid dysfunction

Abstract

Aim. To study an expression of P-glycoprotein in the liver, lean gut, kidneys, cerebral cortex at experimental dysfunction of the thyroid gland. Materials and methods. P-glycoprotein expression was investigated on Chinchilla rabbits by immunohistochemistry method. Serum blood levels of thyroid hormones (general T4, general T3, TTH) was investigated by radioimmune method. Results. It was revealed that in rabbits with experimental hyperthyroidism caused by 14-days subcutaneous admi-nistration of thyroxine expression of P-glycoprotein in the liver, lean gut and cerebral cortex was increased. It was shown that in rabbits with experimental hypothyroidism caused by resection of the thyroid gland or administration of thiamazol within 21 days expression of P-glycoprotein in the liver, lean gut and cerebral cortex was decreased. Conclusion. Correlation dependence between serum levels of general T4, general T3, TTH and an expression of a P-glycoprotein in the liver, lean gut and cerebral cortex was revealed.

Keywords

• p-glycoprotein
• abcb1-protein
• hyperthyroidism
• hypothyroidism
• thiamazol.