Concentration of serum trace elements in leukemia and lymphoma: A case-control study

Abstract

Objective: Trace elements (TEs) have electrochemical and catalytic effects and play a crucial role in metabolism. A change in the concentrations of specific TEs may be associated with the incidence of various diseases such as solid tumors and hematological malignancies. By comparing the concentrations of TEs in the cases and controls, this study aims to provide insights into the possible impacts of TEs concentration on the incidence of leukemia and lymphoma. Materials and methods: In the current study, the serum concentrations of Zn, Cu, Cd, Fe, and Se were analyzed for 20 patients with leukemia and lymphoma and 20 healthy individuals. Those concentrations were measured by atomic absorption spectroscopy. Results: The serum Zn concentration in the cases was significantly lower than that in the controls (P 0.05). Also, the serum concentration of Se was higher in the patients than in the controls, but no significant difference was found (P > 0.05). Conclusion: The results indicate that a low serum concentration of Zn may be associated with the incidence of leukemia and lymphoma. The assessment of TEs in hematological malignancies may be of a prognostic value and provide knowledge about the side effects of alterations in the concentration of those elements. It may also lead to the use of suitable strategies to better manage the clinical conditions of patients.

Keywords

• Leukemia
• Lymphoma
• Trace elements
• Prognostic value