Journal of Inflammation Research (Dec 2021)
The Potential of Drug Delivery Nanosystems for Sepsis Treatment
Abstract
Yi Shi,1,* Meng-Lu Zhu,2,* Qian Wu,1 Yi Huang,1 Xiao-Ling Xu,3 Wei Chen1 1ICU, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People’s Republic of China; 2Department of Pharmacy, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, 310006, People’s Republic of China; 3Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei ChenICU, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 725 South WanPing Road, Shanghai, 200032, People’s Republic of ChinaTel +86-021-64385700-3522Email [email protected] XuShulan International Medical College, Zhejiang Shuren University, 8 Shuren Street, Hangzhou, 310004, People’s Republic of ChinaEmail [email protected]: Sepsis is a major immune response disorder caused by infection, with very high incidence and mortality rates. In the clinic, sepsis and its complications are mainly controlled and treated with antibiotics, anti-inflammatory, and antioxidant drugs. However, these treatments have some shortcomings, such as rapid metabolism and severe side effects. The emergence of drug delivery nanosystems can significantly improve tissue permeability, prolong drugs’ circulation time, and reduce side effects. In this paper, we reviewed recent drug delivery nanosystems designed for sepsis treatment based on their mechanisms (anti-bacterial, anti-inflammatory, and antioxidant). Although great progress has been made recently, clinical practice transformation is still very difficult. Therefore, we also discussed key obstacles, including tissue distribution, overcoming bacterial resistance, and single treatment modes. Finally, a rigorous optimization of drug delivery nanosystems is expected to present great potential for sepsis therapy.Keywords: sepsis, anti-bacterial, anti-inflammatory, anti-oxidative, drug delivery nanosystems, multidrug resistance
