Biofunctional Layered Double Hydroxide Nanohybrids for Cancer Therapy
Joonghak Lee,
Hee Seung Seo,
Wooram Park,
Chun Gwon Park,
Yukwon Jeon,
Dae-Hwan Park
Affiliations
Joonghak Lee
Department of Engineering Chemistry, College of Engineering, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea
Hee Seung Seo
Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon 16419, Gyeonggi, Republic of Korea
Wooram Park
Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Seoburo 2066, Suwon 16419, Gyeonggi, Republic of Korea
Chun Gwon Park
Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon 16419, Gyeonggi, Republic of Korea
Yukwon Jeon
Department of Environmental and Energy Engineering, Yonsei University, Wonju 26493, Gangwondo, Republic of Korea
Dae-Hwan Park
Department of Engineering Chemistry, College of Engineering, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea
Layered double hydroxides (LDHs) with two-dimensional nanostructure are inorganic materials that have attractive advantages such as biocompatibility, facile preparation, and high drug loading capacity for therapeutic bioapplications. Since the intercalation chemistry of DNA molecules into the LDH materials were reported, various LDH nanohybrids have been developed for biomedical drug delivery system. For these reasons, LDHs hybridized with numerous therapeutic agents have a significant role in cancer imaging and therapy with targeting functions. In this review, we summarized the recent advances in the preparation of LDH nanohybrids for cancer therapeutic strategies including gene therapy, chemotherapy, immunotherapy, and combination therapy.
