Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population

Zhe Zhang; Zitao Chen; Shaopan Ye; Yingting He; Shuwen Huang; Xiaolong Yuan; Zanmou Chen; Hao Zhang; Jiaqi Li

doi:10.3390/ani9100732

Animals (Sep 2019)

Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population

Zhe Zhang,
Zitao Chen,
Shaopan Ye,
Yingting He,
Shuwen Huang,
Xiaolong Yuan,
Zanmou Chen,
Hao Zhang,
Jiaqi Li

Affiliations

Zhe Zhang: National Engineering Research Center for Breeding Swine Industry, and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Zitao Chen: National Engineering Research Center for Breeding Swine Industry, and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Shaopan Ye: National Engineering Research Center for Breeding Swine Industry, and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Yingting He: National Engineering Research Center for Breeding Swine Industry, and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Shuwen Huang: National Engineering Research Center for Breeding Swine Industry, and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Xiaolong Yuan: National Engineering Research Center for Breeding Swine Industry, and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Zanmou Chen: National Engineering Research Center for Breeding Swine Industry, and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Hao Zhang: National Engineering Research Center for Breeding Swine Industry, and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Jiaqi Li: National Engineering Research Center for Breeding Swine Industry, and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China

DOI: https://doi.org/10.3390/ani9100732
Journal volume & issue: Vol. 9, no. 10
p. 732

Abstract

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In the pig industry, reproductive traits constantly influence the production efficiency. To identify markers and candidate genes underlying porcine reproductive traits, a genome-wide association study (GWAS) was performed in a Duroc pig population. In total, 1067 pigs were genotyped using single-nucleotide polymorphism (SNP) chips, and four reproductive traits, including litter size at birth (LSB), litter weight at birth (LWB), litter size at weaning (LSW), and litter weight at weaning (LWW), were examined. The results showed that 20 potential SNPs reached the level of suggestive significance and were associated with these traits of interest. Several important candidate genes, including TXN2, KCNA1, ENSSSCG00000003546, ZDHHC18, MAP2K6, BICC1, FAM135B, EPHB2, SEMA4D, ST3GAL1, KCTD3, FAM110A, TMEM132D, TBX3, and FAM110A, were identified and might compose the underlying genetic architecture of porcine reproductive traits. These findings help to understand the genetic basis of porcine reproductive traits and provide important information for molecular breeding in pigs.

Published in Animals

ISSN: 2076-2615 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Agriculture: Animal culture: Veterinary medicine; Science: Zoology
Website: http://www.mdpi.com/journal/animals/

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