Rubber Coring of Injectable Medication Vial Stoppers: An Evaluation of Causal Factors

Abstract

Coring of a medication vial’s rubber stopper has been reported as a major cause of visible particle presence in injectable preparations. In this study, we investigated and quantified visible particle formation caused by coring associated with four potential causal factors.

Keywords

• rubber stoppers
• coring
• particulate matter
• needles
• intravenous administration