Immediate Renal Denervation After Acute Myocardial Infarction Mitigates the Progression of Heart Failure via the Modulation of IL-33/ST2 Signaling

Han Chen; Han Chen; Han Chen; Rui Wang; Rui Wang; Rui Wang; Quan Li; Jiasheng Yin; Jiasheng Yin; Jiasheng Yin; Zhenyi Ge; Fei Xu; Fei Xu; Fei Xu; Tongtong Zang; Tongtong Zang; Tongtong Zang; Zhiqiang Pei; Zhiqiang Pei; Zhiqiang Pei; Chaofu Li; Chaofu Li; Chaofu Li; Li Shen; Li Shen; Li Shen; Junbo Ge; Junbo Ge; Junbo Ge

doi:10.3389/fcvm.2021.746934

Frontiers in Cardiovascular Medicine (Oct 2021)

Immediate Renal Denervation After Acute Myocardial Infarction Mitigates the Progression of Heart Failure via the Modulation of IL-33/ST2 Signaling

Han Chen,
Han Chen,
Han Chen,
Rui Wang,
Rui Wang,
Rui Wang,
Quan Li,
Jiasheng Yin,
Jiasheng Yin,
Jiasheng Yin,
Zhenyi Ge,
Fei Xu,
Fei Xu,
Fei Xu,
Tongtong Zang,
Tongtong Zang,
Tongtong Zang,
Zhiqiang Pei,
Zhiqiang Pei,
Zhiqiang Pei,
Chaofu Li,
Chaofu Li,
Chaofu Li,
Li Shen,
Li Shen,
Li Shen,
Junbo Ge,
Junbo Ge,
Junbo Ge

Affiliations

Han Chen: Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China
Han Chen: National Clinical Research Center for Interventional Medicine, Shanghai, China
Han Chen: Shanghai Institute of Cardiovascular Diseases, Shanghai, China
Rui Wang: Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China
Rui Wang: National Clinical Research Center for Interventional Medicine, Shanghai, China
Rui Wang: Shanghai Institute of Cardiovascular Diseases, Shanghai, China
Quan Li: Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China
Jiasheng Yin: Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China
Jiasheng Yin: National Clinical Research Center for Interventional Medicine, Shanghai, China
Jiasheng Yin: Shanghai Institute of Cardiovascular Diseases, Shanghai, China
Zhenyi Ge: Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China
Fei Xu: Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China
Fei Xu: National Clinical Research Center for Interventional Medicine, Shanghai, China
Fei Xu: Shanghai Institute of Cardiovascular Diseases, Shanghai, China
Tongtong Zang: Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China
Tongtong Zang: National Clinical Research Center for Interventional Medicine, Shanghai, China
Tongtong Zang: Shanghai Institute of Cardiovascular Diseases, Shanghai, China
Zhiqiang Pei: Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China
Zhiqiang Pei: National Clinical Research Center for Interventional Medicine, Shanghai, China
Zhiqiang Pei: Shanghai Institute of Cardiovascular Diseases, Shanghai, China
Chaofu Li: Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China
Chaofu Li: National Clinical Research Center for Interventional Medicine, Shanghai, China
Chaofu Li: Shanghai Institute of Cardiovascular Diseases, Shanghai, China
Li Shen: Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China
Li Shen: National Clinical Research Center for Interventional Medicine, Shanghai, China
Li Shen: Shanghai Institute of Cardiovascular Diseases, Shanghai, China
Junbo Ge: Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China
Junbo Ge: National Clinical Research Center for Interventional Medicine, Shanghai, China
Junbo Ge: Shanghai Institute of Cardiovascular Diseases, Shanghai, China

DOI: https://doi.org/10.3389/fcvm.2021.746934
Journal volume & issue: Vol. 8

Abstract

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Objective: Previous studies have demonstrated the protective effects of renal denervation (RDN) in pre-existing heart failure, but the effects of immediate RDN after acute myocardial infarction (AMI) on subsequent cardiac remodeling have not been reported. This study aimed to investigate the cardioprotective effects of immediate RDN after AMI and its underlying mechanism.Methods: AMI was induced by intracoronary gelatin sponge embolization in 14 Shanghai white pigs that were randomized to undergo either renal angiography (AMI+sham group) or RDN (AMI+RDN group) after 1 h of hemodynamic monitoring. Cardiac function of the two groups was measured at baseline, 1 h post-AMI and at the 1 month follow-up (1M-FU) by transthoracic echocardiography (TTE). Plasma NT-proBNP, soluble ST2 (sST2), norepinephrine (NE), and renin-angiotensin-aldosterone system activity were detected simultaneously. The renal cortex was harvested for NE measurement after the 1M-FU, and the renal arteries were stained with tyrosine hydroxylase for the evaluation of sympathetic activity. Heart tissues in the non-ischemic areas were collected to assess histological and molecular left ventricular (LV) remodeling by pathological staining, RT-PCR, and western blotting.Results: There was no difference in the hemodynamic stability or cardiac function between the two groups at baseline and 1 h post-AMI. Six pigs from each of the two groups completed the 1M-FU. TTE analysis revealed the improved cardiac function of immediate RDN in the AMI+RDN group and circulating NT-proBNP levels were lower than those in the AMI+sham group. Further analysis showed significantly less interstitial fibrosis in the remote non-ischemic myocardium after immediate RDN, together with decreased cardiomyocyte hypertrophy and inflammatory cell infiltration. sST2 levels in circulating and myocardial tissues of animals in the AMI+RDN group were significantly higher than those in the AMI+sham group, accompanied by corresponding alterations in IL-33/ST2 and downstream signaling.Conclusions: Immediate RDN can improve cardiac function and myocardial remodeling after AMI via modulation of IL-33/ST2 and downstream signaling.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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