Menopause Review (Apr 2011)

Ekspresja genu podoplaniny w złośliwych nowotworach jajnika

  • Janusz Kocki,
  • Halina Antosz,
  • Marek Cybulski,
  • Józef Kotarski,
  • Barbara Marzec-Kotarska,
  • Wiesława Bednarek

Journal volume & issue
Vol. 15, no. 2
pp. 102 – 105

Abstract

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Introduction: Ovarian cancer is mostly diagnosed in postmenopausal women. The hormonal microenvironmentof ovarian tumour development in pre- and postmenopausal women is different. The environment mayinfluence the molecular basis of ovarian cancer. Podoplanin is a proven marker of lymphangiogenesis and isengaged in tumour progression and metastasis. Objectives: The aim of our study was to assess podoplanin expression at the mRNA level in ovarian serousand mucinous adenocarcinoma. Material and methods: mRNA expression of podoplanin was assessed in 42 ovarian cancer patients bymeans of real-time PCR. Results: Podoplanin was expressed at the mRNA level in all ovarian cancer patients. It was significantlylower (p < 0.001) in cancer tissues (RQ = 4.46) than in healthy control (RQ = 13.03). No significant differenceswere found in podoplanin expression either between pre- and postmenopausal women or in relation to FIGOand grading. Conclusion: Decreased podoplanin expression is characteristic for serous and mucinous ovarianadenocarcinoma.

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