Communications Biology (Dec 2021)
Nrf2 plays a critical role in the metabolic response during and after spaceflight
- Akira Uruno,
- Daisuke Saigusa,
- Takafumi Suzuki,
- Akane Yumoto,
- Tomohiro Nakamura,
- Naomi Matsukawa,
- Takahiro Yamazaki,
- Ristumi Saito,
- Keiko Taguchi,
- Mikiko Suzuki,
- Norio Suzuki,
- Akihito Otsuki,
- Fumiki Katsuoka,
- Eiji Hishinuma,
- Risa Okada,
- Seizo Koshiba,
- Yoshihisa Tomioka,
- Ritsuko Shimizu,
- Masaki Shirakawa,
- Thomas W. Kensler,
- Dai Shiba,
- Masayuki Yamamoto
Affiliations
- Akira Uruno
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Daisuke Saigusa
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Takafumi Suzuki
- Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
- Akane Yumoto
- JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA
- Tomohiro Nakamura
- Department of Health Record Informatics, Tohoku Medical Megabank Organization, Tohoku University
- Naomi Matsukawa
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Takahiro Yamazaki
- Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University
- Ristumi Saito
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Keiko Taguchi
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Mikiko Suzuki
- Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
- Norio Suzuki
- Division of Oxygen Biology, Tohoku University Graduate School of Medicine
- Akihito Otsuki
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Fumiki Katsuoka
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Eiji Hishinuma
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Risa Okada
- JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA
- Seizo Koshiba
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Yoshihisa Tomioka
- Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University
- Ritsuko Shimizu
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Masaki Shirakawa
- JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA
- Thomas W. Kensler
- Translational Research Program, Fred Hutchinson Cancer Research Center
- Dai Shiba
- JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA
- Masayuki Yamamoto
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- DOI
- https://doi.org/10.1038/s42003-021-02904-6
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 18
Abstract
Akira Uruno et al. report the volume of epidydimal white adipose tissue and plasma glycerophospholipid and sphingolipid levels in mice increase during spaceflight. These metabolic and physiological changes were largely driven by Nrf2 (NF-E2-related factor-2), ultimately providing a mechanistic target for altering lipid metabolism on Earth and the Great Beyond.
