Frontiers in Allergy (Jul 2025)
Gut microbiota-metabolome crosstalk in allergic diseases: mechanistic insights and translational opportunities
- HanBin Qin,
- HanBin Qin,
- HanBin Qin,
- HanBin Qin,
- HanBin Qin,
- Jiaxin Sui,
- Jiaxin Sui,
- Jiaxin Sui,
- Jiaxin Sui,
- Jiaxin Sui,
- Shuang Wang,
- Shuang Wang,
- Shuang Wang,
- Shuang Wang,
- Shuang Wang,
- Xiaojing Lv,
- Xiaojing Lv,
- Xiaojing Lv,
- Xiaojing Lv,
- Zile Zhang,
- Zile Zhang,
- Zile Zhang,
- Zile Zhang,
- Zile Zhang,
- Xinhua Lin,
- Xinhua Lin,
- Xinhua Lin,
- Xinhua Lin,
- Xinhua Lin,
- Xuexia Liu,
- Hua Zhang,
- Hua Zhang,
- Hua Zhang,
- Hua Zhang
Affiliations
- HanBin Qin
- School of Clinical Medicine, Shandong Second Medical University, Weifang, China
- HanBin Qin
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- HanBin Qin
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- HanBin Qin
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- HanBin Qin
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Jiaxin Sui
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Jiaxin Sui
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Jiaxin Sui
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Jiaxin Sui
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Jiaxin Sui
- Qingdao Medical College of Qingdao University, Qingdao, China
- Shuang Wang
- School of Clinical Medicine, Shandong Second Medical University, Weifang, China
- Shuang Wang
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Shuang Wang
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Shuang Wang
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Shuang Wang
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Xiaojing Lv
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Xiaojing Lv
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Xiaojing Lv
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Xiaojing Lv
- Qingdao Medical College of Qingdao University, Qingdao, China
- Zile Zhang
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Zile Zhang
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Zile Zhang
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Zile Zhang
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Zile Zhang
- The 2nd Medical College of Binzhou Medical University, Yantai, China
- Xinhua Lin
- School of Clinical Medicine, Shandong Second Medical University, Weifang, China
- Xinhua Lin
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Xinhua Lin
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Xinhua Lin
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Xinhua Lin
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- Xuexia Liu
- Shandong Stem Cell Engineering Technology Research Center, Central Laboratory, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China
- Hua Zhang
- Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
- Hua Zhang
- Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
- Hua Zhang
- Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
- Hua Zhang
- Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
- DOI
- https://doi.org/10.3389/falgy.2025.1631479
- Journal volume & issue
-
Vol. 6
Abstract
The gut microbiota and its metabolites play important roles in the pathogenesis of various diseases. The diversity of the gut microbiota is closely related to the development and function of the human immune system. Dysbiosis, characterized by alterations in the species, quantity, and distribution of microbial community, may disrupt immune tolerance mechanisms, thereby inducing excessive immune responses to allergens and increasing the risk of allergic diseases. Various metabolites, such as short-chain fatty acids (SCFAs), bile acids, and amino acid metabolites, exert significant regulatory effects on the development of allergic diseases by modulating immune cell function, maintaining intestinal barrier integrity, and participating in signal transduction pathways. A comprehensive investigation into the relationship between allergic diseases and gut microbiota and their metabolites not only aids in elucidating the pathogenesis of allergic diseases but also provides novel insights and a theoretical foundation for developing innovative diagnostic methods, preventive strategies, and therapeutic options. This article systematically reviews the latest findings regarding the mutual influence between gut microbiota and the metabolome in host immune regulation, as well as the impact of this interaction on the development of allergic diseases, aiming to offering new strategies for the prevention and treatment of allergic diseases.
Keywords
