Nature Communications (Oct 2017)

Survival of pancreatic cancer cells lacking KRAS function

  • Mandar Deepak Muzumdar,
  • Pan-Yu Chen,
  • Kimberly Judith Dorans,
  • Katherine Minjee Chung,
  • Arjun Bhutkar,
  • Erin Hong,
  • Elisa M. Noll,
  • Martin R. Sprick,
  • Andreas Trumpp,
  • Tyler Jacks

DOI
https://doi.org/10.1038/s41467-017-00942-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 19

Abstract

Read online

Pancreatic cancer cells may develop resistance to KRAS inhibitors due to activation of compensatory pathways. In this study, the authors demonstrate that KRAS is dispensable in a subset of pancreatic cancer and that PI3K signalling may have an important role in mediating tumor growth following KRAS inhibition.