Nature Communications (Jun 2022)

Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data

  • Daniel Dimitrov,
  • Dénes Türei,
  • Martin Garrido-Rodriguez,
  • Paul L. Burmedi,
  • James S. Nagai,
  • Charlotte Boys,
  • Ricardo O. Ramirez Flores,
  • Hyojin Kim,
  • Bence Szalai,
  • Ivan G. Costa,
  • Alberto Valdeolivas,
  • Aurélien Dugourd,
  • Julio Saez-Rodriguez

DOI
https://doi.org/10.1038/s41467-022-30755-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Multiple methods to infer cell-cell communication (CCC) from single cell data are currently available. Here, the authors systematically compare 16 CCC inference resources and 7 methods, and develop the LIANA framework as an interface to use and compare all these approaches.