Nature Communications (Mar 2020)

The mTOR pathway is necessary for survival of mice with short telomeres

  • Iole Ferrara-Romeo,
  • Paula Martinez,
  • Sarita Saraswati,
  • Kurt Whittemore,
  • Osvaldo Graña-Castro,
  • Lydia Thelma Poluha,
  • Rosa Serrano,
  • Elena Hernandez-Encinas,
  • Carmen Blanco-Aparicio,
  • Juana Maria Flores,
  • Maria A. Blasco

DOI
https://doi.org/10.1038/s41467-020-14962-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Telomerase deficiency leads to age-related diseases and shortened lifespan, while inhibition of the mTOR pathway delays aging. Here, the authors show that inhibition of mTORC1 signaling shortens the lifespan of telomerase deficient mice.