Nature Communications (Mar 2020)

Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase

  • Yu Gao,
  • Hongmei Zhang,
  • Minrui Fan,
  • Chenjun Jia,
  • Lifang Shi,
  • Xiaowei Pan,
  • Peng Cao,
  • Xuelin Zhao,
  • Wenrui Chang,
  • Mei Li

DOI
https://doi.org/10.1038/s41467-020-15268-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Acyl-acyl carrier protein reductase (AAR) and aldehyde deformylating oxygenase (ADO) are the two enzymes in a cyanobacterial alkane biosynthesis pathway that is of interest for biofuel production. Here the authors provide insights into the catalytic mechanisms of AAR and the coupling between the two enzymes by determining the crystal structures of AAR alone and three AAR–ADO complexes with various bound ligands.