Genome Medicine (Jun 2019)

Mechanisms of immune-related adverse events associated with immune checkpoint blockade: using germline genetics to develop a personalized approach

  • Zia Khan,
  • Christian Hammer,
  • Ellie Guardino,
  • G. Scott Chandler,
  • Matthew L. Albert

DOI
https://doi.org/10.1186/s13073-019-0652-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 3

Abstract

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Editorial summary Personalized care of cancer patients undergoing treatment with immune checkpoint inhibitors will require approaches that can predict their susceptibility to immune-related adverse events. Understanding the role of germline genetic factors in determining individual responses to immunotherapy will deepen our understanding of immune toxicity and, importantly, it may lead to tools for identifying patients who are at risk.