Quantitative Bioreactor Monitoring of Intracellular Bacterial Metabolites in Clostridium autoethanogenum Using Liquid Chromatography–Isotope Dilution Mass Spectrometry

• Laudina Safo,
• Salah Abdelrazig,
• Alexander Grosse-Honebrink,
• Thomas Millat,
• Anne M. Henstra,
• Rupert Norman,
• Neil R. Thomas,
• Klaus Winzer,
• Nigel P. Minton,
• Dong-Hyun Kim,
• David A. Barrett

Affiliations

Laudina Safo

Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, Nottingham, U.K.

Salah Abdelrazig

Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, Nottingham, U.K.

Alexander Grosse-Honebrink

Biodiscovery Institute, School of Chemistry, University of Nottingham, Nottingham, U.K.

Thomas Millat

Clostridia Research Group, BBSRC/EPSCR Synthetic Biology Research Centre (SBRC), Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, U.K.

Anne M. Henstra

Clostridia Research Group, BBSRC/EPSCR Synthetic Biology Research Centre (SBRC), Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, U.K.

Rupert Norman

Clostridia Research Group, BBSRC/EPSCR Synthetic Biology Research Centre (SBRC), Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, U.K.

Neil R. Thomas

Biodiscovery Institute, School of Chemistry, University of Nottingham, Nottingham, U.K.

Klaus Winzer

Clostridia Research Group, BBSRC/EPSCR Synthetic Biology Research Centre (SBRC), Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, U.K.

Nigel P. Minton

Clostridia Research Group, BBSRC/EPSCR Synthetic Biology Research Centre (SBRC), Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, U.K.

Dong-Hyun Kim

Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, Nottingham, U.K.

David A. Barrett

Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, Nottingham, U.K.