Comorbidity in patients with acne vulgaris: a current view of the problem

Abstract

The purpose was to summarize the results of scientific studies on the prevalence of comorbid diseases in patients with acne vulgaris and approaches to optimizing management. Мaterials and methods. The analysis and generalization of scientific publications on the prevalence of comorbid diseases in patients with acne vulgaris and modern approaches to the organization of medical care was carried out. Research methods: systematic approach, bibliosemantic. Results. Acne vulgaris is one of the most common dermatological diseases that occurs in all age groups and has a significant impact on the quality of life of patients. According to the results of scientific research, a significant prevalence of comorbid diseases and conditions in patients with acne vulgaris has been established, in particular, changes in hormonal regulation, primarily, violations of the synthesis and metabolism of androgens. There are certain features of androgenic metabolism disorders in women and men, which must be taken into account when prescribing treatment. Changes in the immune system are required to attention among comorbid conditions in patients with acne vulgaris. Modern research has improved the understanding of the immunostimulating function of microorganisms, lipid mediators, neuropeptides and their role in the development of inflammation in acne vulgaris, however, the understanding of all the features of immune activity at different stages of acne vulgaris development remains limited. A significant prevalence of metabolic diseases (obesity, diabetes, disorders of lipid metabolism, etc.) in patients with acne vulgaris has been established, and possible mechanisms of joint co-pathogenesis are considered. The significant prevalence of psychoemotional disorders in patients with acne vulgaris is an important medical and social problem. The results of many studies has been proved that patients with acne vulgaris often have depression, anxiety disorders, social phobia, low self-esteem, etc., which significantly reduce the quality of life of patients, contribute to their maladjustment in social, professional spheres, and family life. The priority direction of optimizing the management of patients with acne vulgaris, in accordance with clinical guidelines and the consensus of experts, is the introduction of a patient-centered approach and shared decision making. Conclusions: Scientific studies have established a significant prevalence of comorbid diseases and conditions in patients with acne vulgaris, which requires optimization of management using a patient-centered approach and involving patients in the treatment process as partners.

Keywords

• acne, skin diseases, comorbidity, patient-centered care