Neutralization capacity of antibodies elicited through homologous or heterologous infection or vaccination against SARS-CoV-2 VOCs

Meriem Bekliz; Kenneth Adea; Pauline Vetter; Christiane S. Eberhardt; Krisztina Hosszu-Fellous; Diem-Lan Vu; Olha Puhach; Manel Essaidi-Laziosi; Sophie Waldvogel-Abramowski; Caroline Stephan; Arnaud G. L’Huillier; Claire-Anne Siegrist; Arnaud M. Didierlaurent; Laurent Kaiser; Benjamin Meyer; Isabella Eckerle

doi:10.1038/s41467-022-31556-1

Nature Communications (Jul 2022)

Neutralization capacity of antibodies elicited through homologous or heterologous infection or vaccination against SARS-CoV-2 VOCs

Meriem Bekliz,
Kenneth Adea,
Pauline Vetter,
Christiane S. Eberhardt,
Krisztina Hosszu-Fellous,
Diem-Lan Vu,
Olha Puhach,
Manel Essaidi-Laziosi,
Sophie Waldvogel-Abramowski,
Caroline Stephan,
Arnaud G. L’Huillier,
Claire-Anne Siegrist,
Arnaud M. Didierlaurent,
Laurent Kaiser,
Benjamin Meyer,
Isabella Eckerle

Affiliations

Meriem Bekliz: Department of Microbiology and Molecular Medicine, University of Geneva
Kenneth Adea: Department of Microbiology and Molecular Medicine, University of Geneva
Pauline Vetter: Division of Infectious Diseases, Geneva University Hospitals
Christiane S. Eberhardt: Center for Vaccinology and Neonatal Immunology, Department of Pathology and Immunology, University of Geneva
Krisztina Hosszu-Fellous: Division of Infectious Diseases, Geneva University Hospitals
Diem-Lan Vu: Division of Infectious Diseases, Geneva University Hospitals
Olha Puhach: Department of Microbiology and Molecular Medicine, University of Geneva
Manel Essaidi-Laziosi: Department of Microbiology and Molecular Medicine, University of Geneva
Sophie Waldvogel-Abramowski: Transfusion Unit, Department of Medicine, Geneva University Hospitals
Caroline Stephan: Transfusion Unit, Department of Medicine, Geneva University Hospitals
Arnaud G. L’Huillier: Pediatric Infectious Diseases Unit, Department of Women, Child and Adolescent Medicine, Geneva University Hospitals and Faculty of Medicine
Claire-Anne Siegrist: Center for Vaccinology and Neonatal Immunology, Department of Pathology and Immunology, University of Geneva
Arnaud M. Didierlaurent: Center for Vaccinology and Neonatal Immunology, Department of Pathology and Immunology, University of Geneva
Laurent Kaiser: Division of Infectious Diseases, Geneva University Hospitals
Benjamin Meyer: Center for Vaccinology and Neonatal Immunology, Department of Pathology and Immunology, University of Geneva
Isabella Eckerle: Department of Microbiology and Molecular Medicine, University of Geneva

DOI: https://doi.org/10.1038/s41467-022-31556-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Emerging SARS-CoV-2 variants raise concerns on protective immunity. Here the authors show that convalescent sera from people infected with Alpha, Beta, Gamma or Delta show a significant drop of Omicron-BA.1 neutralization and that vaccine-breakthrough infections with Omicron-BA.1 or Delta result in robust neutralization for both Delta and Omicron-BA.1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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