Nature Communications (Jul 2021)

TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer

  • Jiahui Xu,
  • Xiaoli Yang,
  • Qiaodan Deng,
  • Cong Yang,
  • Dong Wang,
  • Guojuan Jiang,
  • Xiaohong Yao,
  • Xueyan He,
  • Jiajun Ding,
  • Jiankun Qiang,
  • Juchuanli Tu,
  • Rui zhang,
  • Qun-Ying Lei,
  • Zhi-min Shao,
  • Xiuwu Bian,
  • Ronggui Hu,
  • Lixing Zhang,
  • Suling Liu

DOI
https://doi.org/10.1038/s41467-021-24703-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Vasculogenic mimicry (VM) contributes to the development of triple-negative breast cancer. In this study, the authors show that TEM8 is expressed in VM-forming breast cancer stem cells and it promotes stemness and VM differentiation capacity through a RhoC/ROCK1/SMAD5 axis