Nature Communications (Sep 2021)
A scalable workflow to characterize the human exposome
- Xin Hu,
- Douglas I. Walker,
- Yongliang Liang,
- Matthew Ryan Smith,
- Michael L. Orr,
- Brian D. Juran,
- Chunyu Ma,
- Karan Uppal,
- Michael Koval,
- Greg S. Martin,
- David C. Neujahr,
- Carmen J. Marsit,
- Young-Mi Go,
- Kurt D. Pennell,
- Gary W. Miller,
- Konstantinos N. Lazaridis,
- Dean P. Jones
Affiliations
- Xin Hu
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University
- Douglas I. Walker
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
- Yongliang Liang
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University
- Matthew Ryan Smith
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University
- Michael L. Orr
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University
- Brian D. Juran
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Chunyu Ma
- Huck Institute of the Life Sciences, Penn State University
- Karan Uppal
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University
- Michael Koval
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University
- Greg S. Martin
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University
- David C. Neujahr
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University
- Carmen J. Marsit
- Department of Environmental Health, Rollins School of Public Health at Emory University
- Young-Mi Go
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University
- Kurt D. Pennell
- School of Engineering, Brown University
- Gary W. Miller
- Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University
- Konstantinos N. Lazaridis
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Dean P. Jones
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, School of Medicine at Emory University
- DOI
- https://doi.org/10.1038/s41467-021-25840-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Humans are exposed to millions of chemicals but mass spectrometry (MS)-based targeted biomonitoring assays are usually limited to a few hundred known hazards. Here, the authors develop a workflow for MS-based untargeted exposome profiling of known and unidentified environmental chemicals.
