Nature Communications (Jul 2020)

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

  • Amine Toubal,
  • Badr Kiaf,
  • Lucie Beaudoin,
  • Lucie Cagninacci,
  • Moez Rhimi,
  • Blandine Fruchet,
  • Jennifer da Silva,
  • Alexandra J. Corbett,
  • Yannick Simoni,
  • Olivier Lantz,
  • Jamie Rossjohn,
  • James McCluskey,
  • Philippe Lesnik,
  • Emmanuelle Maguin,
  • Agnès Lehuen

DOI
https://doi.org/10.1038/s41467-020-17307-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 20

Abstract

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Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage populations and inducing dysbiosis of the intestinal microbiota.