Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide
Li Wang,
Aili Wang,
William W. Supplee,
Kayla Koffler,
Ying Cheng,
Zenaide M.N. Quezado,
Richard J. Levy
Affiliations
Li Wang
The Sheikh Zayed Institute for Pediatric Surgical Innovation, Division of Pain Medicine, Children׳s National Health System, Children׳s Research Institute, The George Washington University School of Medicine and Health Sciences, United States
Aili Wang
Department of Anesthesiology, Columbia University Medical Center, United States
William W. Supplee
Rutgers New Jersey Medical School, United States
Kayla Koffler
Department of Anesthesiology, Columbia University Medical Center, United States
Ying Cheng
Center for Genetic Medicine Research, Children׳s National Health System, Children׳s Research Institute, The George Washington University School of Medicine and Health Sciences, United States
Zenaide M.N. Quezado
The Sheikh Zayed Institute for Pediatric Surgical Innovation, Division of Pain Medicine, Children׳s National Health System, Children׳s Research Institute, The George Washington University School of Medicine and Health Sciences, United States
Richard J. Levy
Department of Anesthesiology, Columbia University Medical Center, United States; Corresponding author.
The data presented here detail the changes in size, cellular content, and neuronal density of the developing brain over time with respect to sex in C57Bl/6 mice following neonatal exposure to isoflurane, carbon monoxide, or their combination. Specifically, brain weight- and brain volume-to-body weight ratios are presented, representative immunoblots of whole brain cell-specific protein content are depicted, and quantification of the number of neurons in the primary somatosensory cortex and CA3 region of the hippocampus are shown. Three discrete postnatal time points are represented: P7 (prior to exposure), P14 (one-week post exposure), and P42-56 (5–7 weeks post exposure). Major findings from the data presented here are reported in the manuscript “Carbon Monoxide Incompletely Prevents Isoflurane-induced Defects in Murine Neurodevelopment'' (Wang et al., in press) [1].
