175 A Fas-4–1BB immunomodulatory fusion protein converts a pro-death to a pro-survival signal, enhancing T cell function and efficacy of adoptive cell therapy in murine models of AML and pancreatic cancer

• Shannon Oda,
• Kristin Anderson,
• Philip Greenberg,
• Nicolas Garcia,
• Pranali Ravikumar,
• Patrick Bonson,
• Cody Jenkins,
• Summer Zhuang,
• Andrew Daman

Affiliations

Shannon Oda

1Seattle Children’s Research Institute, Seattle, WA, USA

Kristin Anderson

2University of Washington, Seattle, USA

Philip Greenberg

3Fred Hutchinson Cancer Research Center, Seattle, WA, USA

Nicolas Garcia

3Fred Hutchinson Cancer Research Center, Seattle, WA, USA

Pranali Ravikumar

3Fred Hutchinson Cancer Research Center, Seattle, WA, USA

Patrick Bonson

3Fred Hutchinson Cancer Research Center, Seattle, WA, USA

Cody Jenkins

3Fred Hutchinson Cancer Research Center, Seattle, WA, USA

Summer Zhuang

3Fred Hutchinson Cancer Research Center, Seattle, WA, USA

Andrew Daman

3Fred Hutchinson Cancer Research Center, Seattle, WA, USA