Effect of benzofurocainum on blood microcirculation in the attached gum in conditions of sound parodentium and experimental periodontitis

Abstract

It was found that during the experiments on rats assisted by the Doppler flowmetering method the benzofurocainum (BF) lowers the erythrocyte flow and its fluctuation in the capillary race of the attached gum (AG) of the lower incisors by the intraperitoneal introduction in the dosage of 10 mg/kg in conditions of sound parodentium during 40 min (most evidently on the 10th min). In addition the vasomotor activity remains stable in comparison with the initial one, that can be conditioned by the increase of the general peripheric vessel resistance. In conditions of experimental periodontitis (EP) the blood microcirculation (BMC) in AG undergoes essential changes to lowering. The use of the traditional medicamental therapy (TMT) against the background of EP causes the increment in BMC in the chosen area after 12 days of treatment; one month later BMC decreases. The combination ТМТ + BF in taken conditions of the experiment induces the increment in BMC immediately after the treatment as well as one month after the use, besides BMC reaches the initial level.

Keywords

• здоровый пародонт
• экспериментальный пародонтит
• прикрепленная десна
• микроциркуляция крови
• бензофурокаин
• sound parodentium
• experimental periodontitis
• attached gum
• blood microcirculation
• benzofurocainum