Alternative Splicing of FOXP3—Virtue and Vice

Reiner K. W. Mailer; Reiner K. W. Mailer

doi:10.3389/fimmu.2018.00530

Frontiers in Immunology (Mar 2018)

Alternative Splicing of FOXP3—Virtue and Vice

Reiner K. W. Mailer,
Reiner K. W. Mailer

Affiliations

Reiner K. W. Mailer: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Reiner K. W. Mailer: Cardiovascular Medicine Unit, Department of Medicine, Karolinska Insititutet, Stockholm, Sweden

DOI: https://doi.org/10.3389/fimmu.2018.00530
Journal volume & issue: Vol. 9

Abstract

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FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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