Van Tıp Dergisi (Jan 2021)
Comparison of SUVmax values obtained from F-18 FDG PET/CT and YKL-40 levels measured from serum in the evaluation of lung lesions
Abstract
INTRODUCTION: Fluorine‐18‐fluorodeoxyglucose (18F‐FDG) positron emission tomography (PET)/computed tomography (CT) is a trusted method for the evaluation of cancer patients. In this study, we aimed to calculate the SUVmax values for semi-quantitative evaluation in patients with pulmonary lesions undergoing diagnostic PET / CT study and to investigate serum YKL-40 and ischemia modified albumin (IMA) levels. METHODS: We performed a prospective case-control during July 2012-July 2013. Patients referred to the nuclear medicine clinics with suspected pulmonary lesions were enrolled in the study prospectively. In this study we analyzed 85 patients who underwent routine PET/CT imaging for suspicious lung masses. Of the included patients, 20 (23.5%) had BLD, while 65 (76.5%) had lung cancer (LC) in the pathological examination of the lesions. Additionally, 35 participants from the patient relatives were enrolled as healthy controls. SUVmax were calculated in patients who underwent PET / CT study, and serum samples of YKL 40, IMA, carcinoembryonic antigen (CEA) and lactate dehydrogenase (LDH) values were measured. RESULTS: Patients with LC had higher mean SUVmax values compared to the BLD group (9.49+-2.27 vs. 3.13+-1.15) (p<0.001). Serum YKL-40 (71,42+-7,65ng/L and102.03+-12.22 ng/L vs. 31,79+-7,52 ng/L), IMA (0,90+-0,16 and 0,84+-0.09 vs. 0,70+-0,08), LDH (268,00+-63,30 U/L and 261.03+-65,02 U/L vs. 165,08,00+-52,62 U/L), and CEA (4,60+-1,10 ng/mL and 2,47+-0.81 ng/mL vs. 1,9+-0,41 ng/mL) measurements remained greater in patients having LC and BLD than the healthy participants (p<0.001). DISCUSSION AND CONCLUSION: In this study we concluded that SUVmax and serum YKL‐40 levels were increased in LC cases. SUVmax may be an efficient variable to distinguish LC from BLD.
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