Mediators of Inflammation (Jan 2019)

Effects of Anti-Cytokine Antibodies on Gut Barrier Function

  • Fang Liu,
  • Seul A. Lee,
  • Stephen M. Riordan,
  • Li Zhang,
  • Lixin Zhu

DOI
https://doi.org/10.1155/2019/7028253
Journal volume & issue
Vol. 2019

Abstract

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Anti-cytokine antibodies are used in treating chronic inflammatory diseases and autoimmune diseases such as inflammatory bowel disease and rheumatic diseases. Patients with these diseases often have a compromised gut barrier function, suggesting that anti-cytokine antibodies may contribute to the re-establishment of gut barrier integrity, in addition to their immunomodulatory effects. This paper reviews the effects of anti-cytokine antibodies on gut barrier function and their mechanisms.