Some peculiarities of immunobiochemical disorders in pathogenesis of pseudoexfoliation syndrome

Abstract

ABSTRACT Purpose. To measure concentrations of transforming growth factor-β1 (TGF-β1), matrix-metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) in the lacrima of cataract patients with pseudoexfoliation syndrome (PEX). Material and methods. Determination of the concentrations of IL-6, TGF-β1 and MMP-9 in lacrima was performed by the immune-enzyme analysis method in 71 cataract patients (71 eyes) with pseudoexfoliation syndrome (PEX) aged from 50 to 92 years (76±0.91). Results. It was found a significant increase of the concentrations of IL-6, TGF-β1 and MMP-9 in lacrima of patients with PEX. Conclusions. Increase of IL-6 and MMP-9 level may play an important role in the PEX pathogenesis. These cytokines are involved in the development of «subclinical» inflammatory process and activate the processes of destruction and proliferation. TGF-β1 has significant proliferative and anti-inflammatory activity. Increase of TGF-β1 level activates the processes of fibrosis and may be one of the pathogenetic factors in the formation of pseudoexfoliation material.

Keywords

• pseudoexfoliation syndrome
• tear
• transforming growth factors
• matrix metalloproteinases
• cytokines.