Alzheimer’s disease serum lipids levels in Siberia

Abstract

Background: Previous studies examining the association of serum lipids levels with the risk for development of Alzheimer disease (AD) have been inconclusive. Objective: To evaluate the serum lipids levels in persons suffering from AD. Methods: 147 patients suffering from AD (according to NINCDS/ADRDA criteria) of both sexes from the Novosibirsk city were examined. Concentration of serum lipids were assessed by enzymatic method. Cognitive functions were determined by Mini-mental State Examination Scale (MMSE). Results: Patients’ serum lipids levels were corresponded to norms according to European and American Recommendations. Patients’ serum lipids levels were not statistically significant distinguished from those in long-livers from the Novosibirsk city and Yakutia. Statistically significant associations between serum total cholesterol, low-density lipoprotein cholesterol (LDL-CH), high-density lipoprotein cholesterol (HDL-CH) levels and patients’ age, as well as MMSE score were not revealed in correlation analysis. Conclusion: Serum lipids levels were not associated with risk for development of AD in examined patients’ group.

Keywords

• alzheimer disease
• cognitive functions
• serum lipids