Malformações congênitas em regiões de monocultivo no estado de Minas Gerais, Brasil

Abstract

Objective: to analyze the association between the use of agrochemicals and congenital malformations in municipalities with greater exposure, as well as to evaluate the nature of the correlation between the trend observed and the volume of agrochemicals considered as endocrine disruptors in the state of Minas Gerais, Brazil, between 1994 and 2014. Model Study: Cross-sectional study, exploratory, descriptive and quantitative character. Method: Rates of malformations for the periods 1994-2003 and 2004-2014 were calculated from the information on live births available at SINASC/Ministry of Health. Odds Ratio tested the association between types of malformations and variables for each variable separately. The significance was set at p<0.05. Results: there was an increasing trend in the rates of congenital malformation in the state of Minas Gerais, especially at Triângulo Mineiro/Alto Paraíba and Vale do Mucuri/Jequitinhonha regions. It was found that the rates for congenital malformations were higher for the years of greatest exposure (2004-2014) and had a statistically significant association for all congenital malformations in the state of Minas Gerais. Conclusion: Maternal exposure to pesticides was related with higher incidence of congenital malformations.

Keywords

• Congenital Abnormalities. Agrochemicals. Environmental Exposure. Endocrine Disruptors.