CRISPR-Cas12a Nucleases Bind Flexible DNA Duplexes without RNA/DNA Complementarity

• Wei Jiang,
• Jaideep Singh,
• Aleique Allen,
• Yue Li,
• Venkatesan Kathiresan,
• Omair Qureshi,
• Narin Tangprasertchai,
• Xiaojun Zhang,
• Hari Priya Parameshwaran,
• Rakhi Rajan,
• Peter Z. Qin

Affiliations

Wei Jiang

†Department of Chemistry, University of Southern California, Los Angeles, California, United States

Jaideep Singh

†Department of Chemistry, University of Southern California, Los Angeles, California, United States

Aleique Allen

†Department of Chemistry, University of Southern California, Los Angeles, California, United States

Yue Li

†Department of Chemistry, University of Southern California, Los Angeles, California, United States

Venkatesan Kathiresan

†Department of Chemistry, University of Southern California, Los Angeles, California, United States

Omair Qureshi

†Department of Chemistry, University of Southern California, Los Angeles, California, United States

Narin Tangprasertchai

†Department of Chemistry, University of Southern California, Los Angeles, California, United States

Xiaojun Zhang

†Department of Chemistry, University of Southern California, Los Angeles, California, United States

Hari Priya Parameshwaran

Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma, United States

Rakhi Rajan

Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma, United States

Peter Z. Qin

†Department of Chemistry, University of Southern California, Los Angeles, California, United States